Mesothelioma

Mesothelioma is a form of cancer that is almost always caused by previous exposure to asbestos. In this disease, malignant cells develop in the mesothelium, a protective lining that covers most of the body's internal organs. Its most common site is the pleura (outer lining of the lungs and chest cavity), but it may also occur in the peritoneum (the lining of the abdominal cavity) or the pericardium (a sac that surrounds the heart).

Asbestos:

Asbestos has been used in building-construction materials, textiles, missile and jet parts, asphalt and caulking compounds and paints, and in friction products such as brake linings. Exposure to asbestos fibers and dust, however, can cause asbestosis, a disease of the lungs caused by the inhalation of asbestos particles, and, after a latent period of up to 30 years and more, various cancers, especially lung cancer and mesothelioma, which is an inoperable cancer of the chest and abdominal lining (see Occupational and Environmental Diseases). At present no wholly satisfactory substitutes are available for asbestos in many of its applications; because of health risks posed by asbestos use, however, research into replacements has been accelerated. In 1986 the Environmental Protection Agency proposed an immediate ban on the major uses of asbestos and a complete ban on all asbestos products within the next decade. This proposal was partially overturned by the U.S. Court of Appeals, which limited the ban to asbestos flooring and new products using asbestos.


Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or they have been exposed to asbestos dust and fibre in other ways, such as by washing the clothes of a family member who worked with asbestos. Unlike lung cancer, there is no association between mesothelioma and smoking.

The symptoms of mesothelioma include shortness of breath due to pleural effusion (fluid between the lung and the chest wall) or chest wall pain, and general symptoms such as weight loss. The diagnosis can be made with chest X-rays and a CT scan, and confirmed with a biopsy (tissue sample) and microscopic examination. A thoracoscopy (inserting a tube with a camera into the chest) can be used to take biopsies. It allows the introduction of substances such as talc to obliterate the pleural space (called pleurodesis), which prevents more fluid from accumulating and pressing on the lung. Despite treatment with chemotherapy, radiation therapy or sometimes surgery the disease carries a poor prognosis. Research about screening tests for the early detection of mesothelioma is ongoing.

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